Results
| PMID | 19931078 |
| Gene Name | AQP2 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 70 |
| Population details | 70 women with endometriomas |
| Sex | Female |
| Associated genes | Aquaporins 2, 5, 8 |
| Other associated phenotypes |
Endometriosis |
|
Fertil Steril. 2010 Sep;94(4):1229-34. doi: 10.1016/j.fertnstert.2009.08.053. Jiang, Xiu-Xiu| Wu, Riu-Jin| Xu, Kai-Hong| Zhou, Cai-Yun| Guo, Xiao-Yan| Sun, Ya-Li| Lin, Jun Department of Gynecology and Obstetrics, Women's Hospital, Zhejiang University Medical College, Zhejiang Province, Hangzhou City, People's Republic of China. OBJECTIVE: To investigate the expression of aquaporin (AQP) in eutopic and ectopic endometrial tissues from women with endometriomas. DESIGN: Controlled laboratory research. SETTING: Hospital-based unit for gynecology and obstetrics and research laboratories. PATIENT(S): Premenopausal women undergoing laparoscopy for endometriomas. INTERVENTION(S): Endometrial biopsy samples obtained from 70 women with endometriomas. MAIN OUTCOME MEASURE(S): Semiquantitative analysis by immunohistochemistry. RESULT(S): Aquaporins 2, 5, and 8 were mainly located in luminal and glandular epithelia. The frequency of positive immunostaining for aquaporins 2, 5, and 8 decreased in ectopic compared with eutopic endometria. Aquaporins 2, 5, and 8 were found at a low frequency in the endometria in early proliferative phases but at a higher frequency in late proliferative and secretory phases. There were no significant differences in the menstrual cycle of the proliferative phase and secretory phase in the two groups. CONCLUSION(S): Aquaporins 2, 5, and 8 were expressed with greater frequency in eutopic endometrial cells than inectopic endometrial cells, suggesting that eutopic endometrial cells have stronger migration activity than ectopic endometrial cells in women with endometriosis. Mesh Terms: Adult| Aquaporins/*metabolism| Choristoma/*metabolism/pathology| Endometriosis/*metabolism/pathology| Endometrium/*metabolism/pathology| Female| Humans| Immunohistochemistry| Menstrual Cycle/metabolism/physiology| Middle Aged| Peritoneal Disease |
|